558.680—Zoalene.

(a) Specifications. Type A medicated article containing 25 percent zoalene.

(b) Approvals. See No. 046573 in § 510.600(c) of this chapter.

(d) Conditions of use— (1) Chickens and turkeys:

Zoalene in grams/ton	Combination in grams/ton	Indications for use	Limitations
(i) 36.3-113.5 (0.004-0.0125%).		Replacement chickens; development of active immunity to coccidiosis.	Grower ration not to be fed to birds over 14 weeks of age; as follows:

Growing conditions	Starter rationGrams per ton	Grower rationGrams per ton
Severe exposure	113.5 (0.0125%)	75.4-113.5 (0.0083%-0.0125%)
Light to moderate exposure	75.4-113.5 (0.0083%-0.0125%)	36.3-75.4 (0.004%-0.0083%)

Zoalene in grams/ton	Combination in grams/ton	Indications for use	Limitations
	Arsanilic acid 90 (0.01%).	Replacement chickens; development of active immunity to coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable in item (i).
	Arsanilic acid 90 (0.01%) plus erythromycin 4.6 to 18.5.	Replacement chickens; growth promotion and feed efficiency; development of active immunity to coccidiosis; improving pigmentation.	As erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable item (i).
	Arsanilic acid 90 (0.01%) plus erythromycin 92.5.	1. Replacement chickens; as an aid in the prevention of chronic respiratory disease during periods of stress; development of active immunity to coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Feed for 2 d before stress and 3 to 6 d after stress; as erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic arsenic; feed as in subtable in item (i).
		2. Replacement chickens; as an aid in the prevention of infectious coryza; development of active immunity to coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Feed for 7 to 14 d; as erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable in item (i).
	Arsanilic acid 90 (0.01%) plus erythromycin 185.	Replacement chickens; as an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease; growth promotion and feed efficiency; improving pigmentation and development of active immunity to coccidiosis.	Feed for 5 to 8 d; do not use in birds producing eggs for food purposes; withdraw 5 d before slaughter; as erythromycin thiocyanate; as sole source of organic arsenic; feed as in subtable in item (i).
	Arsanilic acid 90 (0.01%) plus penicillin 2.4 to 50.	Replacement chickens; growth promotion and feed efficiency; development of active immunity to coccidiosis; improving pigmentation.	As procaine penicillin; grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable in item (i).
	Bacitracin 4 to 50	Replacement chickens: For development of active immunity to coccidiosis; for increased rate of weight gain, improved feed efficiency	Feed as in subtable in § 558.680(d)(1)(i) ; grower ration not to be fed to birds over 14 weeks of age. As bacitracin methylene disalicylate provided by No. 046573 in § 510.600(c) of this chapter.
	Bacitracin methylene disalicylate 4 to 50 plus roxarsone 22.7 to 45.4	Replacement chickens: For development of active immunity to coccidiosis; for increased rate of weight gain, improved feed efficiency, and improved pigmentation	Feed as in subtable in § 558.680(d)(1)(i) ; grower ration not to be fed to birds over 14 weeks of age. Discontinue use 5 days before slaughter; as sole source of organic arsenic; drug overdose or lack of water may result in leg weakness. As bacitracin methylene disalicylate and roxarsone provided by No. 046573 in § 510.600(c) of this chapter.
Code of Federal Regulations 517
	Bacitracin methylenedisalicylate 50	Replacement chickens; development of active immunity to coccidiosis; as an aid in the prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin.	Feed continuously as sole ration as in subtable in this item (i); grower ration not to be fed to birds over 14 weeks of age. Bacitracin methylene disalicylate as provided by 046573 in § 510.600(c) of this chapter.
	Bacitracin methylene disalicylate 100 to 200	Replacement chickens; development of active immunity to coccidiosis; as an aid in the control of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin.	Feed continuously as sole ration as in subtable in this item (i). To control necrotic enteritis, start medication at first clinical signs of disease; vary bacitracin dosage based on the severity of infection; administer continuously for 5 to 7 days or as long as clinical signs persist, then reduce bacitracin to prevention level (50 grams/ton). Bacitracin methylene disalicylate as provided by 046573 in § 510.600(c) of this chapter.
	Bacitracin 100 to 500.	Replacement chickens; treatment of chronic respiratory disease (air-sac infection); blue comb (nonspecific infectious enteritis); development of active immunity to coccidiosis.	As bacitracin zinc; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).

	Chlortetracycline 100 to 200.	Replacement chickens; development of active immunity to coccidiosis; control of infectious synovitis caused by Mycoplasma synoviae susceptible to chlortetracycline.	Do not feed to chickens producing eggs for human consumption; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Chlortetracycline 200 to 400.	Replacement chickens; development of active immunity to coccidiosis; control of chronic respiratory disease (CRD) and air sac infection caused by M. gallisepticum and Escherichia coli susceptible to chlortetracycline.	Do not feed to chickens producing eggs for human consumption; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Erythromycin 4.6 to 18.5.	Replacement chickens; growth promotion and feed efficiency; development of active immunity to coccidiosis.	As erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Erythromycin 92.5.	1. Replacement chickens, as an aid in the prevention of chronic respiratory disease during periods of stress; development of active immunity to coccidiosis.	Feed for 2 d before stress and 3 to 6 after stress; withdraw 24 hours (h) before slaughter; as erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
		2. Replacement chickens; as an aid in the prevention of infectious coryza; development of active immunity to coccidiosis.	Feed for 7 to 14 d; withdraw 24 h before slaughter; as erythromycin thiocyanate; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Erythromycin 185.	Replacement chickens; as an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease; development of active immunity to coccidiosis.	Feed for 5 to 8 d; do not use in birds producing eggs for food purposes; withdraw 48 h before slaughter; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
Code of Federal Regulations 518
	Hygromycin B 8 to 12.	Replacement chickens; development of active immunity to coccidiosis; control of infestation of large round worms (Ascaris galli) cecal worms (Heterakis gallinae) and capillary worms (Capillaria obsignate).	Grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Penicillin 2.4 to 50.	Replacement chickens; growth promotion and feed efficiency; development of active immunity to coccidiosis.	As procaine penicillin; grower ration not to be fed to birds over 14 weeks of age; feed as in subtable in item (i).
	Penicillin 2.4 to 50 plus roxarsone 22.7 to 45.4 (0.0025% to 0.005%).	Replacement chickens; growth promotion and feed efficiency; development of active immunity to coccidiosis; improving pigmentation.	As procaine penicillin; grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable in item (i).
	Roxarsone 22.7 to 45.5 (0.0025% to 0.005%).	Replacement chickens; development of active immunity to coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Grower ration not to be fed to birds over 14 weeks of age; withdraw 5 d before slaughter; as sole source of organic arsenic; feed as in subtable in item (i).
(ii) 113.5 (0.0125%).		Broiler chickens; prevention and control of coccidiosis.
	Arsanilic acid 90 (0.01%).	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis; improving pigmentation.	Withdraw 5 d before slaughter; as sole source of organic arsenic.
	Arsanilic acid 90 (0.01%) plus erythromycin 4.6 to 18.5.	Broiler chickens; growth prevention and control of coccidiosis; improving pigmentation.	As erythromycin thiocyanate; withdraw 5 d before slaughter; as sole source of organic arsenic.
	Arsanilic acid 90 (0.01%) plus erythromycin 92.5.	1. Broiler chickens; as an aid in the prevention of chronic respiratory disease during periods of stress; growth promotion and feed efficiency; improving pigmentation; control of coccidiosis.	Do.
		2. Broiler chickens; prevention and control of coccidiosis; growth promotion and feed efficiency; improving pigmentation; as an aid in the prevention of infectious coryza.	Do.
	Arsanilic acid 90 (0.01%) plus erythromycin 185.	Broiler chickens; as an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease; prevention and control of coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Feed for 5 to 8 d; do not use in birds producing eggs for food purposes; as erythromycin thiocyanate; withdraw 5 d before slaughter; as sole source of organic arsenic.
	Arsanilic acid 90 (0.01%) plus penicillin 2.4 to 50.	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis; improving pigmentation.	As procaine penicillin; withdraw 5 d before slaughter; as sole source of organic arsenic.
	Arsanilic acid 90 (0.01%) plus bacitracin 4 to 50.	Broiler chickens; prevention and control of coccidiosis; improving pigmentation; growth promotion and feed efficiency.	Withdraw 5 d before slaughter; as sole source of organic arsenic; as bacitracin methylene disalicylate.
	Bacitracin 4 to 50.	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis.	As bacitracin methylene disalicylate or zinc bacitracin.
Code of Federal Regulations 519
	Bacitracin 4 to 50 plus roxarsone 22.7 to 45.4 (0.0025 to 0.005%).	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis; improving pigmentation.	As bacitracin methylene disalicylate or zinc bacitracin; withdraw 5 d before slaughter; as sole source of organic arsenic.
	Bacitracin methylene disalicylate 50	Broiler chickens; prevention and control of coccidiosis; as an aid in the prevention of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin.	Feed continuously as sole ration. Bacitracin methylene disalicylate as provided by 046573 in § 510.600(c) of this chapter.
	Bacitracin methylene disalicylate 100 to 200	Broiler chickens; prevention and control of coccidiosis; as an aid in the control of necrotic enteritis caused or complicated by Clostridium spp. or other organisms susceptible to bacitracin.	Feed continuously as sole ration. To control necrotic enteritis, start medication at first clinical signs of disease; vary bacitracin dosage based on the severity of infection; administer continuously for 5 to 7 days or as long as clinical signs persist, then reduce bacitracin to prevention level (50 grams/ton). Bacitracin methylene disalicylate as provided by 046573 in § 510.600(c) of this chapter.
	Bacitracin 100 to 500.	Broiler chickens; treatment of chronic respiratory disease (air-sac infection); blue comb (nonspecific infectious enteritis); prevention and control of coccidiosis.	As zinc bacitrain.
	Bambermycins 1	Broiler chickens: As an aid in the prevention and control of coccidiosis; and for increased rate of weight gain and improved feed efficiency.	Feed continuously as sole ration. Do not feed to chickens over 14 weeks of age. Bambermycins as provided by No. 016592 in § 510.600(c) of this chapter.
	Bambermycins 1 plus roxarsone 22.7	Broiler chickens: As an aid in the prevention and control of coccidiosis; and for increased rate of weight gain and improved feed efficiency.	Feed continuously as sole ration. Do not feed to chickens over 14 weeks of age; feed as sole source of organic arsenic; withdraw 5 days before slaughter. Bambermycins as provided by No. 016592, roxarsone by No. 046573 in § 510.600(c) of this chapter.
	Chlortetracycline 100 to 200	Broiler chickens; prevention and control of coccidiosis; control of infectious synovitis caused by M. synoviae susceptible to chlortetracycline.	Do not feed to chickens producing eggs for human consumption; feed continuously for 7 to 14 d.
	Chlortetracycline 200 to 400	Broiler chickens; prevention and control of coccidiosis; control of chronic respiratory disease (CRD) and air sac infection caused by M. gallisepticum and E. coli susceptible to chlortetracycline.	Do not feed to chickens producing eggs for human consumption; feed continuously for 7 to 14 d.
	Erythromycin 4.6 to 18.5.	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis.	As erythromycin thiocyanate.
	Erythromycin 92.5.	1. Broiler chickens; as an aid in the prevention of chronic respiratory disease during period of stress; prevention and control of coccidiosis.	Feed for 2 d before stress and 3 to 6 d after stress; withdraw 24 h before slaughter; as erythromycin thiocyanate.
		2. Broiler chicken; as an aid in the prevention of infectious coryza; prevention and control of coccidiosis.	Feed for 7 to 14 d; withdraw 24 h before slaughter; as erythromycin thiocyanate.
Code of Federal Regulations 520
	Erythromycin 185.	Broiler chickens; as an aid in the prevention and reduction of lesions and in lowering severity of chronic respiratory disease; prevention and control of coccidiosis.	Feed for 5 to 8 d; do not use in birds producing eggs for food purposes; withdraw 48 h before slaughter; as erythromycin thiocyanate.
	Hygromycin B 8 to 12.	Broiler chickens; prevention and control of coccidiosis; control of infestation of large round worms (Ascaris galli) cecal worms (Heterakis gallinae) and capillary worms (Capillaria obsignate) .
	Lincomycin 2.	Broiler chickens; increase in rate of weight gain; improved feed efficiency; as an aid in the prevention and control of coccidiosis.	Do not feed to laying chickens; to be fed as the sole ration; as lincomycin hydrochloride monohydrate provided by No. 000009 in § 510.600(c) of this chapter.
	Penicillin 2.4 to 50.	Broiler chickens; growth promotion and feed efficiency; prevention and control of coccidiosis.	As procaine penicillin.
	Penicillin 2.4 to 50 plus roxarsone 22.7 to 45.4 (0.0025 to 0.005%).	Broiler chickens; prevention and control of coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Withdraw 5 d before slaughter; as sole source of organic arsenic; as procaine penicillin.
	Roxarsone 22.7 to 45.4 (0.0025 to 0.005%).	Broiler chickens; prevention and control of coccidiosis; growth promotion and feed efficiency; improving pigmentation.	Withdraw 5 d before slaugher; as sole source of organic arsenic.
(iii) 113.5 to 170.3 (0.0125 to 0.01875%).		Turkeys; prevention and control of coccidiosis.	For turkeys grown for meat purposes only.
	Arsanilic acid 90(0.01%).	do.	Do.
	Bacitracin methylene disalicylate 4-50.	Turkeys; prevention and control of coccidiosis, and increased rate of weight gain and improved feed efficiency.	For turkeys grown for meat purposes only, not to be fed to laying birds, feed continuously as sole ration until 14 to 16 weeks of age.
	Carbarsone (not U.S.P.) 277 to 340.5 (0.025% to 0.0375%).	Turkeys; prevention and control of coccidiosis; aid in the prevention of blackhead.	For turkeys grown for meat purposes only; feed continuously beginning 2 weeks before blackhead and coccidiosis are expected and continue as long as prevention of blackhead and prevention and control of coccidiosis is needed; withdraw 5 d before slaughter; as sole source of organic arsenic.
	Roxarsone 22.7 to 45.4 (0.0025% to 0.005%).	Turkeys; growth promotion and feed efficiency; improving pigmentation.	Withdraw 5 d before slaughter; as sole source of organic arsenic.

(2) Zoalene may also be used in combination with roxarsone as in § 558.530.

Code of Federal Regulations

[41 FR 11005, Mar. 15, 1976, as amended at 42 FR 18618, Apr. 8, 1977; 42 FR 20817, Apr. 22, 1977; 42 FR 36995, July 19, 1977; 51 FR 7401, Mar. 3, 1986; 52 FR 2686, Jan. 26, 1987; 55 FR 8461, Mar. 8, 1990; 57 FR 8403, Mar. 10, 1992; 57 FR 8578, Mar. 11, 1992; 61 FR 35957, July 9, 1996; 63 FR 38750, July 20, 1998; 67 FR 6868, Feb. 14, 2002; 71 FR 16223, Mar. 31, 2006; 71 FR 27958, May 15, 2006; 76 FR 17027, Mar. 28, 2011]

CFR

558.680—Zoalene.

Code of Federal Regulations