CFR

558.600—Tiamulin.

(a) Specifications. Type A article containing 5, 10, or 113.4 grams of tiamulin (as tiamulin hydrogen fumarate) per pound.

(b) Approvals. See No. 058198 in § 510.600(c) of this chapter.

(d) Special considerations— (1) Swine being treated with tiamulin should not have access to feeds containing polyether ionophores (e.g., lasalocid, monensin, narasin, salinomycin, or semduramycin) as adverse reactions may occur. If signs of toxicity occur, discontinue use.

(2) The effects of tiamulin on swine reproductive performance, pregnancy, and lactation have not been determined.

(3) Use as sole source of tiamulin.

(e) Conditions of use— (1) Swine. It is used as follows:

Tiamulin in grams per ton	Combination in grams per ton	Indications for use	Limitations	Sponsor
(i) 10		For increased rate of weight gain and improved feed efficiency	Feed continuously as the sole ration. Not for use in swine weighing over 250 pounds	058198
(ii) 35		1. For control of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin	Feed continuously as sole ration on premises with a history of swine dysentery but where signs of disease have not yet occurred or following approved treatment of disease. Withdraw 2 days before slaughter	058198
		2. For control of porcine proliferative enteropathies (ileitis) associated with Lawsonia intracellularis	Feed continuously as the sole ration for not less than 10 days. Withdraw 2 days before slaughter	058198
(iii) 35	Chlortetracycline, approximately 400 (varying with body weight and feed consumption to provide 10 milligrams of chlortetracycline per pound of body weight daily)	For treatment of swine bacterial enteritis caused by Escherichia coli and Salmonella choleraesuis and bacterial pneumonia caused by Pasteurella multocida susceptible to chlortetracycline, and control of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin	Feed continuously as sole ration for 14 days. Use as only source of chlortetracycline. Withdraw 2 days before slaughterAs chlortetracycline calcium complex, Type A medicated articles containing the equivalent of 50 to 100 grams per pound of chlortetracycline hydrochloride provided by 046573 and 048164 in § 510.600(c) of this chapter	048164, 058198
(iv) 200		For treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin	Feed continuously as the sole feed for 14 consecutive days. Withdraw feed 7 days before slaughter	058198

(2) [Reserved]

Code of Federal Regulations

[67 FR 7268, Feb. 19, 2002, as amended at 69 FR 62407, Oct. 26, 2004; 70 FR 75018, Dec. 19, 2005; 74 FR 6, Jan. 2, 2009]

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